Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
- AChromosomes will be fragmented
- BChromosomes will not segregate
- CRecombination of chromosome arms will occur
- DChromosomes will not condense
Solution & Step-by-step Explanation
The APC triggers the transition from metaphase to anaphase by targeting proteins like securin for degradation. If APC is defective, sister chromatids will not separate, and therefore chromosomes will fail to segregate.