Choose the group of letters which is different from the others:

Let's analyze the presence of vowels and consonants in each group:
* DXCLQZ: D, X, C, L, Q, Z are all consonants.
* PFZUBM: P, F, Z, B, M are consonants, but U is a vowel.
* XGKNTY: X, G, K, N, T, Y are all consonants.
* GJMQVX: G, J, M, Q, V, X are all consonants.

Since PFZUBM is the only group that contains a vowel, it is the odd one out.