If $+$ means $-$, $-$ means $\times$, $\times$ means $÷$, and $÷$ means $+$, what will come in place of the question mark (?) in the given equation?
$$22\times 11-450÷50+500=?$$

First, let's substitute the original operational signs with their designated actual operational meanings:
* $\times \to ÷$
* $-\to \times$
* $÷\to +$
* $+\to -$

Rewriting the modified equation:

$$22÷11\times 450+50-500=?$$

Evaluating step-by-step using the BODMAS rule:

1. Division: $22÷11=2$

$$2\times 450+50-500=?$$

2. Multiplication: $2\times 450=900$

$$900+50-500=?$$

3. Addition: $900+50=950$

$$950-500=?$$

4. Subtraction: $950-500=450$

Thus, the value is $450$.