If $+$ means $-$, $-$ means $\times$, $\times$ means $÷$, and $÷$ means $+$, then what will come in place of the question mark ($?$) in the given equation?
$$22\times 11-450÷50+500=?$$

Substitute the signs according to the given instructions:
* Replace $\times$ with $÷$
* Replace $-$ with $\times$
* Replace $÷$ with $+$
* Replace $+$ with $-$

The new equation becomes:

$$22÷11\times 450+50-500=?$$

Now, apply the BODMAS rule:

1. Division: $22÷11=2$

$$2\times 450+50-500=?$$

2. Multiplication: $2\times 450=900$

$$900+50-500=?$$

3. Addition: $900+50=950$

$$950-500=?$$

4. Subtraction: $950-500=450$

Therefore, $?=450$.