Read the following four statements $(A-D)$. Which are the two statements having mistakes?$(A)$ The first transgenic buffalo Rosie produced milk which was human alpha-lactalbumin enriched.$(B)$ Restriction enzymes are used in isolation of $\text{DNA}$ from other macro-molecules.$(C)$ Downstream processing is one of the steps of $\text{R-DNA}$ technology.$(D)$ Disarmed pathogen vectors are also used in transfer of $\text{R-DNA}$ into the host.

1. A
   Statements $(A)$ and $(C)$
2. B
   Statements $(A)$ and $(B)$
3. C
   Statements $(B)$ and $(C)$
4. D
   Statements $(C)$ and $(D)$