Select the combination of numbers so that the letters arranged accordingly will form a meaningful word:
$${\text{P}}_1{\text{N}}_2{\text{O}}_3{\text{A}}_4{\text{C}}_5{\text{L}}_6{\text{M}}_7{\text{I}}_8$$

Let's decode the options by substituting the letters associated with the given numbers:
* Option A: 2, 7, 8, 6, 4, 3, 1, 5 $\to$ N M I L A O P C
* Option B: 4, 7, 5, 2, 6, 8, 1, 3 $\to$ A M C N L I P O
* Option C: 5, 3, 7, 1, 6, 4, 8, 2 $\to$ C O M P L A I N
* Option D: 7, 1, 8, 5, 6, 2, 4, 3 $\to$ M P I C L N A O

Option C forms the perfectly meaningful English word "COMPLAIN".