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Select the option which is not correct with respect to enzyme action:

  1. A
    Substrate binds with enzyme at its active site.
  2. B
    Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
  3. C
    A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.
  4. D
    Malonate is a competitive inhibitor of succinic dehydrogenase.

Solution & Step-by-step Explanation

Shutterstock Explore In competitive inhibition (like malonate inhibiting succinic dehydrogenase), the inhibitor and substrate compete for the same active site. This inhibition can be reversed by significantly increasing the substrate (succinate) concentration. Thus, statement (B) is incorrect.

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Try it yourself before checking the explanation above.

Select the option which is not correct with respect to enzyme action:
A
Substrate binds with enzyme at its active site.
B
Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
C
A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.
D
Malonate is a competitive inhibitor of succinic dehydrogenase.

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