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Sickle cell anemia is:

  1. A
    caused by substitution of valine by glutamic acid in the beta globin chain.
  2. B
    caused by a change in a single base pair of .
  3. C
    characterized by elongated sickle like with a nucleus.
  4. D
    an autosomal linked dominant trait.

Solution & Step-by-step Explanation

Sickle cell anemia is a point mutation where a single base pair change in the (GAG to GTG) results in the substitution of glutamic acid by valine at the sixth position of the beta-globin chain. (Option A has the substitution backwards).

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Sickle cell anemia is:
A
caused by substitution of valine by glutamic acid in the beta globin chain.
B
caused by a change in a single base pair of .
C
characterized by elongated sickle like with a nucleus.
D
an autosomal linked dominant trait.

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Principles of InheritanceGenetic DisordersMutation

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