Statements related to human insulin are given below: Which statement(s) is/are correct about genetically engineered Insulin?(a) Pro-hormone insulin contain extra stretch of C-peptide.(b) A-peptide and B-peptide chains of insulin were produced separately in E. coli, extracted and combined by creating a disulphide bond between them.(c) Insulin used for treating Diabetes was extracted from Cattles and Pigs.(d) Pro-hormone insulin needs to be processed for converting into a mature and functional hormone.(e) Some patients develop allergic reactions to the foreign insulin.Choose the correct answer from the options given below:
- A(a), (b) and (d) only
- B(b) only
- C(c) and (d) only
- D(c), (d) and (e) only
Solution & Step-by-step Explanation
1. (a) and (d) are about natural human insulin maturation, not the genetically engineered process.2. (c) and (e) refer to the historical use of animal-derived insulin and its drawbacks.3. (b) is correct: This describes the specific methodology used by Eli Lilly to produce humulin (recombinant insulin) without needing the C-peptide/pro-hormone step.