The next term in the sequence 4, 10, 22, 46, ________ is

Let's look at the pattern in the differences between consecutive terms:
* $10-4=6$
* $22-10=12$
* $46-22=24$

The differences are $6,12,24,\dots$, which are doubling each time ($6\times 2=12$, $12\times 2=24$).
Therefore, the next difference must be $24\times 2=48$.

The next term in the sequence is:

$$46+48=94$$

*(Alternative pattern: Each term is obtained by $2n+2$. For example, $4\times 2+2=10$; $10\times 2+2=22$; $22\times 2+2=46$; $46\times 2+2=94$.)*