The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of:
- AAcyl chloride > Ester > Acid anhydride > Amide
- BAcyl chloride > Acid anhydride > Ester > Amide
- CEster > Acyl chloride > Amide > Acid anhydride
- DAcid anhydride > Amide > Ester > Acyl chloride