Under which of the following conditions will there be no change in the reading frame of following mRNA? AACAGCGGUGCUAUU
- AInsertion of G at 5th position
- BDeletion of G from 5th position
- CInsertion of A and G at 4th and 5th positions respectively
- DDeletion of GGU from 7th, 8th and 9th positions
Solution & Step-by-step Explanation
Reading frame is determined by codons (groups of 3 bases).Insertion or deletion of 1 or 2 bases (Options A, B, C) shifts the entire reading frame (frameshift mutation).Deletion (or insertion) of exactly 3 bases (or multiples of 3) removes (or adds) one entire codon but does not change the reading frame for the rest of the sequence. GGU is one codon.