With regard to insulin choose correct options:
(a) C-peptide is not present in mature insulin.
(b) The insulin produced by rDNA technology has C-peptide.
(c) The pro-insulin has C-peptide.
(d) A-peptide and B-peptide of insulin are interconnected by disulphide bridges.
Choose the correct answer from the options given below:
- A(a), (c) and (d) only
- B(a) and (d) only
- C(b) and (d) only
- D(b) and (c) only
Solution & Step-by-step Explanation
(a) is correct: Mature insulin consists of A and B chains; the C-peptide is removed during maturation.
(b) is incorrect: rDNA insulin (Humulin) is produced by synthesizing A and B chains separately and then joining them; it does not contain C-peptide.
(c) is correct: Pro-insulin contains an extra stretch called the C-peptide.
(d) is correct: The A and B chains are linked by disulphide bonds.
Options (a), (c), and (d) are correct.
(b) is incorrect: rDNA insulin (Humulin) is produced by synthesizing A and B chains separately and then joining them; it does not contain C-peptide.
(c) is correct: Pro-insulin contains an extra stretch called the C-peptide.
(d) is correct: The A and B chains are linked by disulphide bonds.
Options (a), (c), and (d) are correct.